Advanced Glycation End Products Downregulate Connexin 43 and Connexin 40 in Diabetic Atrial Myocytes via the AMPK Pathway.

Fan YangHuan-Huan LiuLei ZhangXiao-Lu ZhangJie ZhangFeng LiNing ZhaoZhi-Yuan ZhangQi KongXiao-Yu LiuYing WuZhi-Ming YuLing-Ling QianRu-Xing Wang

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2023)

Thus, we conclude that AGEs cause dysregulation of Cx43 and Cx40 in diabetic atria via the AMPK pathway, thereby leading to gap junction dysfunction, which may contribute to the increased AF susceptibility in diabetes.

Keyphrases

type diabetes
atrial fibrillation
skeletal muscle
wound healing
cardiovascular disease
oxidative stress
protein kinase
glycemic control
left atrial
metabolic syndrome
insulin resistance
left ventricular
weight loss
mitral valve