MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.
Derrick A BennettSarah ParishIona Y MillwoodYu GuoYiping ChenIain TurnbullLing YangJun LvCanqing YuGeorge Davey SmithYongjun WangYilong WangRichard PetoRory CollinsRobin G WaltersLiming LiZhengming ChenRobert J Clarkenull nullPublished in: International journal of epidemiology (2023)
In Chinese adults, the MTHFR C677T polymorphism was associated with higher risks of stroke. The findings warrant corroboration by further trials of folic acid and implementation of mandatory folic acid fortification programmes for stroke prevention in low-folate populations.