CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism.

Luke W ThomasCinzia EspositoJenna M StephenAna S H CostaChristian FrezzaThomas S BlackerGyorgy SzabadkaiMargaret Ashcroft

Published in: Cancer & metabolism (2019)

CHCHD4 drives tumour cell growth and activates mTORC1 signalling through its control of respiratory chain mediated metabolism and complex I biology, and also regulates EMT-related phenotypes of tumour cells.

Keyphrases

epithelial mesenchymal transition
induced apoptosis
cell cycle arrest
respiratory tract
cell death
endoplasmic reticulum stress