M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics.

Lizhe GuoLu WangGang QinJunjie ZhangJin PengLongyan LiXiang ChenDandan WangJian QiuE Wang

Published in: Journal of translational medicine (2023)

Disruption of PKM2 tetramerization contributed to RVF by inducing mitochondrial fragmentation, accumulating ROS, and finally promoted the progression of cardiomyocyte apoptosis. Facilitating PKM2 tetramerization holds potential as a promising therapeutic approach for RVF.

Keyphrases

oxidative stress
dna damage
diabetic rats
ischemia reperfusion injury
induced apoptosis
cell death
pulmonary hypertension
pulmonary artery
angiotensin ii
mitral valve
endoplasmic reticulum stress
protein kinase
cell cycle arrest
mouse model
risk assessment
human health
congenital heart disease