The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.

Fei GuoTaniya FernandoXiao-Yong ZhuYingli Shi

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2022)

In addition to the central regulation, local ovarian overexpression of the NKB-NK3R system participated in the adverse reproductive endocrine phenotypes, supporting the therapeutic implications of NK3Ra for PCOS.

Keyphrases

polycystic ovary syndrome
cell proliferation
nk cells
transcription factor
rheumatoid arthritis
insulin resistance
emergency department
binding protein
electronic health record