Toxoplasma gondii profilin and tachyzoites RH strain may manipulate autophagy via downregulating Atg5 and Atg12 and upregulating Atg7.

Sara NematiHossein PazokiHanieh Mohammad RahimiHamid Asadzadeh AghdaeiShabnam ShahrokhKaveh BaghaeiHamed MirjalaliMohammad Reza Zali

Published in: Molecular biology reports (2021)

Our findings suggest that T. gondii and profilin may manipulate autophagy via preventing from the formation of Atg5-12-16L complex to facilitate replication of T. gondii and development of toxoplasmosis.

Keyphrases

toxoplasma gondii
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress