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Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice.

Yueying ZhouXiaonan XinLichao WangBinsheng WangLi ChenOusheng LiuDavid W RoweMing Xu
Published in: NPJ Regenerative medicine (2021)
The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.
Keyphrases
  • bone marrow
  • mesenchymal stem cells
  • bone mineral density
  • bone regeneration
  • stem cells
  • metabolic syndrome
  • type diabetes
  • machine learning
  • risk assessment
  • bone loss
  • postmenopausal women