Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM).
Anna Materna-KirylukKatarzyna WisniewskaKatarzyna B KubiakJolanta WierzbaAnna JazdzewskaBeata Jaroszewska-SwiatekKinga SkotnickaAnna Latos-BielenskaPublished in: Children (Basel, Switzerland) (2021)
Data from the Polish Registry of Congenital Malformations (PRCM) suggest that the prevalence of limb reduction defects (LRDs) in some Polish regions is significantly higher in comparison to that reported in the European Surveillance of Congenital Anomalies (EUROCAT) registry, but specific risk factors are still unknown. The objectives of this study were two-fold: to detect risk factors linked to isolated LRDs among Polish natives and to search for geospatial clusters of isolated LRDs to identify high-risk areas across the country. Among the 2,939,001 births accounted for in the PRCM, we determined that there were 852 children with distinct LRDs. Our data demonstrate that lower birth weight, prematurity, and maternal smoking history are strongly associated with isolated LRDs. Furthermore, our investigation pointed to various additional risk factors for isolated LRDs, including paternal education, gestational hypertension, upper respiratory tract infections, and exposure to anti-inflammatory drugs in the first trimester of pregnancy. We did not recognize statistically significant spatial or spatiotemporal clusters over the area of Poland using Kulldorff's scan. Our study strengthens the hypothesis that maternal factors have an integral role in the etiology of isolated LRDs.
Keyphrases
- birth weight
- risk factors
- gestational age
- weight gain
- pregnancy outcomes
- respiratory tract
- electronic health record
- big data
- blood pressure
- pregnant women
- healthcare
- anti inflammatory drugs
- body mass index
- public health
- computed tomography
- young adults
- physical activity
- machine learning
- data analysis
- weight loss
- contrast enhanced
- water quality