Electrochemical Decarboxylative N-Alkylation of Heterocycles.
Tao ShengHai-Jun ZhangMing ShangChi HeJulien C VantouroutPhil S BaranPublished in: Organic letters (2020)
An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.