Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids.
Yue CaoShenghua HanHan ZhangJie WangQiao-Yan JiangYimin ZhouYou-Jia YuJianfang WangFeng ChenDennis K P NgPublished in: Journal of materials chemistry. B (2022)
A nanoprobe based on polydopamine-coated gold nanobipyramids surface modified with molecules of a phenylboronic acid-substituted distyryl boron dipyrromethene has been fabricated and characterised using various physical and spectroscopic methods. It serves as an ultrasensitive sensor for sialic acids on the surface of cancer cells based on its dual surface-enhanced Raman scattering and fluorescence response. This biomarker can also trigger the photodynamic activity of these nanobipyramids, effectively eradicating the cancer cells mainly through apoptosis as shown by various bioassays.
Keyphrases
- cell surface
- molecular docking
- oxidative stress
- cancer therapy
- mental health
- endoplasmic reticulum stress
- physical activity
- gold nanoparticles
- label free
- single molecule
- quantum dots
- magnetic nanoparticles
- helicobacter pylori infection
- mass spectrometry
- highly efficient
- cell proliferation
- signaling pathway
- living cells
- molecularly imprinted
- tandem mass spectrometry
- fluorescent probe