PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes.

Jiajie TuWeile ChenYilong FangDafei HanYizhao ChenHaifeng JiangXuewen TanZhen XuXuming WuHuihui WangXiangling ZhuWenming HongZhenbao LiChen ZhuXinming WangWei Wei

Published in: Annals of the rheumatic diseases (2022)

These results support the role of PU.1 in RA and may have therapeutic implications by directly repressing FLT3. Therefore, targeting PU.1 might be a potential therapeutic approach for RA.

Keyphrases

rheumatoid arthritis
acute myeloid leukemia
disease activity
tyrosine kinase
ankylosing spondylitis
interstitial lung disease
systemic lupus erythematosus
drug delivery
wound healing