Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.

Yongjie WangBuyi ZhangJianli WangHaijian WuShenbin XuJianmin ZhangLin Wang

Published in: Cell communication and signaling : CCS (2021)

Our results demonstrated the central role of CMA in mediating N-CoR degradation and protecting GBM cells against UPR and apoptosis, and provided evidence of LAMP-2A as potential biomarker. Further research focusing on CMA with other tumorigenic process is needed and selective modulators of LAMP-2A remain to be investigated to provide a novel therapeutic strategy for GBM. Video Abstract.

Keyphrases

cell cycle arrest
loop mediated isothermal amplification
cell death
endoplasmic reticulum stress
induced apoptosis
pi k akt
small molecule
oxidative stress
signaling pathway
sensitive detection
high throughput
atomic force microscopy
mass spectrometry
single cell
high speed