Cytokine-induced interleukin-1 receptor antagonist protein expression in genetically engineered equine mesenchymal stem cells for osteoarthritis treatment.

Simone GabnerReinhard ErtlKarsten VeldeMatthias RennerFlorien JennerMonika EgerbacherJuraj Hlavaty

Published in: The journal of gene medicine (2018)

Thus, pro-inflammatory cytokine induced IL-1Ra protein expression from genetically modified MSCs might represent a promising strategy for osteoarthritis treatment.

Keyphrases

mesenchymal stem cells
rheumatoid arthritis
high glucose
umbilical cord
stem cells
knee osteoarthritis
combination therapy
oxidative stress
cell therapy
ankylosing spondylitis
systemic sclerosis