APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.
Brandon C FarmerHolden C WilliamsNicholas A DevanneyMargaret A PironGrant K NationDavid J CarterAdeline E WalshRebika KhanalLyndsay E A YoungJude C KluemperGabriela HernandezElizabeth J AllengerRachel MooneyLesley R GoldenCathryn T SmithJ Anthony BrandonVedant A GuptaPhilip A KernMatthew S GentryJosh M MorgantiRamon C SunLance A JohnsonPublished in: Molecular neurodegeneration (2021)
Together, these results suggest astrocyte, brain and system-level metabolic reprogramming in the presence of APOE4, a 'Warburg like' endophenotype that is observable in young females decades prior to clinically manifest AD.