PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.
Le ZhangJustine BailleulTaha YazalKevin DongDavid SungAmy DaoLaura GosaDavid NathansonKruttika BhatSara Duhachek-MuggyClaudia AlliMilana Bochkur DratverFrank PajonkErina VlashiPublished in: Breast cancer research and treatment (2019)
Radiotherapy can induce metabolic changes in TNBC cells, and these changes seem to be mediated, at least in part by PK-M2. Importantly, our results show that activators of PK-M2 can deplete breast cancer stem cells in vitro. This study supports the idea of combining PK-M2 activators with radiation to enhance the effect of radiotherapy in resistant cancers, such as TNBC.