Mesenchymal Stromal Cell Implants for Chronic Motor Deficits After Traumatic Brain Injury: Post Hoc Analysis of a Randomized Trial.

David O OkonkwoPeter McAllisterAchal S AchrolYasuaki KarasawaMasahito Kawabori Steven C CramerAlbert LaiSantosh KesariBenjamin M FrishbergLeonid I GroysmanAnthony S KimNeil E SchwartzJefferson W ChenHideaki ImaiTakao YasuharaDai ChidaBijan NejadnikDamien BatesAnthony H StonehouseRobert Mark RichardsonGary K SteinbergEugene C PoggioAlan H Weintraub

Published in: Neurology (2024)

This study provides Class I evidence that intracranial implantation of allogeneic stem (SB623) cells in adults with motor deficits from chronic TBI improves motor function at 24 weeks.

Keyphrases

traumatic brain injury
bone marrow
induced apoptosis
stem cell transplantation
stem cells
cell cycle arrest
single cell
cell therapy
endoplasmic reticulum stress
cell death
low dose
drug induced
signaling pathway
soft tissue
pi k akt