Effects of long-acting muscarinic antagonists on promoting ciliary function in airway epithelium.
Mineo KatsumataTomoyuki FujisawaYosuke KamiyaYuko TanakaChiaki KamiyaYusuke InoueHironao HozumiMasato KarayamaYuzo SuzukiKazuki FuruhashiNoriyuki EnomotoYutaro NakamuraNaoki InuiMasato MaekawaMitsutoshi SetouHiroshi WatanabeKoji IkegamiTakafumi SudaPublished in: BMC pulmonary medicine (2022)
LAMAs exert a direct effect on airway epithelium to enhance ciliary function, which may improve impaired MCC in asthma and COPD. Further investigations are warranted to elucidate the underlying mechanisms of the effects of LAMAs on the promotion of airway ciliary function.