P2X7 receptor-nitric oxide interaction mediates apoptosis in mouse immortalized mesangial cells exposed to high glucose.

Thamires de Oliveira Fernandes Adelson Marçal Rodrigues Giovana Rita Punaro Deyse Yorgos de Lima Elisa Mieko Suemitsu Higa

Published in: Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia (2021)

The main finding was that the production of NO by iNOS was positively correlated with the increase of P2X7 in MCs under HG conditions, showing that there is a common stimulus between them and that NO interacts with the P2X7 pathway, contributing to apoptosis in experimental DM. These findings could be relevant to studies of therapeutic targets for the prevention and/or treatment of hyperglycemia-induced kidney damage to delay DN progression.

Keyphrases

high glucose
cell cycle arrest
endothelial cells
oxidative stress
cell death
induced apoptosis
endoplasmic reticulum stress
nitric oxide
pi k akt
diabetic rats
nitric oxide synthase
signaling pathway
cell proliferation
case control
single molecule