Clustered 8-Oxo-Guanine Mutations and Oncogenic Gene Fusions in Microsatellite-Unstable Colorectal Cancer.

Russell W MadisonXiaoju HuVivek Ramanan Zhuxuan Xu Richard S P Huang Ethan S Sokol Garrett M Frampton Alexa B Schrock Siraj M Ali Shridar Ganesan Subhajyoti De

Published in: JCO precision oncology (2022)

Detailed analysis of breakpoints in MSI-associated KFs support a model in which inefficient repair and/or processing of microbiome-induced clustered 8-oxoguanine damage in MSI CRC contributes to the increased incidence of specific oncogenic fusions.

Keyphrases

transcription factor
high glucose
diabetic rats
risk factors
genome wide
copy number
drug induced
endothelial cells
gene expression
genome wide analysis