The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint.
Chuang-Chi LiawHung ChangTzu-Yao LiaoMing-Sheng WenChih-Teng YuYu-Hsiang JuanPublished in: Journal of oncology (2016)
Background. We studied the role of pulmonary veins in cancer progression using computed tomography (CT) scans. Methods. We obtained data from 260 patients with pulmonary vein obstruction syndrome (PVOS). We used CT scans to investigate pulmonary lesions in relation to pulmonary veins. We divided the lesions into central and peripheral lesions by their anatomical location: in the lung parenchymal tissue or pulmonary vein; in the superior or inferior pulmonary vein; and by unilateral or bilateral presence in the lungs. Results. Of the 260 PVOS patients, 226 (87%) had central lesions, 231 (89%) had peripheral lesions, and 190 (75%) had mixed central and peripheral lesions. Among the 226 central lesions, 93% had lesions within the superior pulmonary vein, either bilaterally or unilaterally. Among the 231 peripheral lesions, 65% involved bilateral lungs, 70% involved lesions within the inferior pulmonary veins, and 23% had obvious metastatic extensions into the left atrium. All patients exhibited nodules within their pulmonary veins. The predeath status included respiratory failure (40%) and loss of consciousness (60%). Conclusion. CT scans play an important role in following tumor progression within pulmonary veins. Besides respiratory distress, PVOS cancer cells entering centrally can result in cardiac and cerebral events and loss of consciousness or can metastasize peripherally from the pulmonary veins to the lungs.
Keyphrases
- computed tomography
- pulmonary hypertension
- dual energy
- inferior vena cava
- contrast enhanced
- end stage renal disease
- image quality
- magnetic resonance imaging
- chronic kidney disease
- heart failure
- small cell lung cancer
- peritoneal dialysis
- young adults
- magnetic resonance
- case report
- machine learning
- deep learning
- squamous cell
- extracorporeal membrane oxygenation
- electronic health record
- atrial fibrillation
- blood brain barrier