Prodromal sensory neuropathy in Pink1-/- SNCAA53T double mutant Parkinson mice.

Lucie ValekBao TranAnnett Wilken-SchmitzSandra TrautmannJuliana HeidlerTobias SchmidBernhard BrüneDominique ThomasThomas DellerGerd GeisslingerGeorg AuburgerIrmgard Tegeder

Published in: Neuropathology and applied neurobiology (2021)

The results suggest that pathological GlcCer contribute to prodromal sensory disease in PD mice via mitochondrial damage and calcium channel hyperexcitability. GlcCer-associated sensory neuron pathology might be amenable to GlcCer lowering therapeutic strategies.

Keyphrases

high fat diet induced
oxidative stress
parkinson disease
wild type
type diabetes