Urinary oestrogen steroidome as an indicator of the risk of localised prostate cancer progression.

Jean-Philippe EmondLouis LacombePatrick CaronVéronique TurcotteDavid SimonyanArmen AprikianFred SaadMichel CarmelSimone ChevalierChantal Guillemette Eric Lévesque

Published in: British journal of cancer (2021)

Our data suggest that urinary levels of oestriol and 16-ketoestradiol metabolites are associated with a more favourable outcome, whereas those of 2-methoxyestrone are associated with an elevated risk of metastasis after RP. Further studies are required to better understand the impact of oestrogens on disease biology and as easily accessible urine-based risk-stratification markers.

Keyphrases

prostate cancer
radical prostatectomy
ms ms
electronic health record
big data
machine learning
data analysis
artificial intelligence