Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection.

Inês T FreitasWillard TinagoHirofumi SawaJulie McAndrewsBrenda DoakCharlotte Prior-FullerGerard SheehanJohn S LambertEavan MuldoonAoife G CotterWilliam W HallPatrick W G MallonMichael J Carr

Published in: AIDS research and therapy (2020)

In virally-suppressed, long-term ART-treated PLWH, rs368234815 ΔG/ΔG homozygotes were more likely to have attained normalisation of their CD4+:CD8+ ratio, displayed lower CD4+ effector memory and higher naive CD8+ T-cells. Further studies are needed to replicate our findings in other, larger and more diverse cohorts and to determine the impact of IFNL genetic-variation on CD4+:CD8+ ratio normalisation and clinical outcomes in PLWH.

Keyphrases

hiv infected
dendritic cells
antiretroviral therapy
nk cells
regulatory t cells
working memory
newly diagnosed