Evaluation of a Liquid Biopsy-Breast Cancer Methylation (LBx-BCM) Cartridge Assay for Predicting Early Disease Progression and Survival: TBCRC 005 Prospective Trial.

Kala Visvanathan Leslie Cope Mary Jo Fackler Michael Considine Lori J Sokoll Lisa Anne Carey Andres Forero-Torres James N Ingle Nancy U Lin Rita Nanda Anna Maria V Storniolo Suzana Tulac Neesha Venkatesan Natalie C Wu Sudhakar Marla Scott A Campbell Michael N Bates Christopher B Umbricht Antonio C Wolff Saraswati Sukumar

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

The automated LBx-BCM prototype assay is a promising clinical tool for detecting disease progression a month after initiating treatment in women with MBC undergoing routine care. The next step is to validate its clinical utility for specific treatments.

Keyphrases

high throughput
healthcare
palliative care
dna methylation
study protocol
clinical trial
quality improvement
phase iii
genome wide
deep learning
clinical practice
ultrasound guided
gene expression
phase ii
single cell
replacement therapy