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Characterizing the etiology of recurrent tuberculosis using whole genome sequencing-Alaska, USA, 2008-2020.

Yuri P SpringerMegan L TompkinsKatherine NewellMartin JonesScott BurnsBruce ChandlerLauren S CowanJ Steve KammererJames E PoseyKala M RazMichelle RothoffBenjamin J SilkYvette L VergnettiJoseph B McLaughlinSarah Talarico
Published in: The Journal of infectious diseases (2024)
WGS and attribution criteria involving genetic distances and patterns of relatedness can provide an effective means of elucidating rTB etiology. Our findings indicate that rTB occurs at high proportions among AIAN persons in Alaska and is frequently attributable to reinfection, reinforcing the importance of active surveillance and control measures to limit the spread of TB disease in Alaskan AIAN communities.
Keyphrases
  • mycobacterium tuberculosis
  • genome wide
  • pulmonary tuberculosis
  • hiv aids
  • copy number
  • gene expression
  • dna methylation
  • adverse drug
  • electronic health record