SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis.

Xiaomeng FengHan SuXiaochen HeJian-Xiong ChenHeng Zeng

Published in: Cells (2020)

Our study suggests that SIRT3 deficiency sensitized Ang-II-induced renal fibrosis by the mechanisms involved in promoting differentiation of pericytes into fibroblasts, exacerbating iron overload and accelerating NADPH oxidase-derived ROS formation.

Keyphrases

angiotensin ii
diabetic rats
high glucose
angiotensin converting enzyme
oxidative stress
vascular smooth muscle cells
drug induced
ischemia reperfusion injury
liver fibrosis
signaling pathway
smoking cessation