Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice.
Peng LiangWeiran ShanZhi-Yi ZuoPublished in: Journal of neuroinflammation (2018)
These results suggest that cefazolin has a direct anti-inflammatory effect and can attenuate surgery-induced postoperative memory and learning impairment in mice. Cefazolin alone may induce cognitive dysfunction possibly by transient gut dysbiosis in mice without surgery.
Keyphrases
- high fat diet induced
- patients undergoing
- minimally invasive
- coronary artery bypass
- anti inflammatory
- oxidative stress
- type diabetes
- diabetic rats
- surgical site infection
- metabolic syndrome
- insulin resistance
- working memory
- acute kidney injury
- skeletal muscle
- drug induced
- high glucose
- atrial fibrillation
- acute coronary syndrome
- endothelial cells
- percutaneous coronary intervention
- brain injury