Herpes Simplex Virus Hepatitis in Patients Requiring Intensive Care Unit Admission: A Retrospective, Multicenter, Observational Study.
Thomas FrapardGiuliana AmaddeoMaxens DecavelePaer-Selim AbbackAntoine GailletCharlotte BouzbibClaire VanlemmensRomy YounanEmmanuel CanetAnne Sophie MoreauMathilde NeuvilleElie AzoulayAlexandre SitbonDjamel MokartSylvie RadenneArmand AbergelCéline GuichonOlivier RouxAgnes BonadonaArmand Mekontso DessapAudrey De JongJerome DumortierNicolas De Prostnull nullPublished in: Open forum infectious diseases (2023)
The clinical features and short-term prognosis of patients admitted to the intensive care unit for herpes hepatitis are lacking. Of 33 patients admitted between 2006 and 2022, 22 were immunocompromised, 4 were pregnant women, and 23 died. Sixteen patients developed a hemophagocytic syndrome. Acyclovir was initiated a median (interquartile range) of 1 (0-3) day after admission.