Viruses as tools in gene therapy, vaccine development, and cancer treatment.
Musab Bin UmairFujimura Nao AkusaHadia Kashifnull Seerat-E-FatimaFatima ButtMarium AzharIqra MunirMuhammad AhmedWajeeha KhalilHafiz SharyarShazia RafiqueMuhammad ShahidSamia AfzalPublished in: Archives of virology (2022)
Using viruses to our advantage has been a huge leap for humanity. Their ability to mediate horizontal gene transfer has made them useful tools for gene therapy, vaccine development, and cancer treatment. Adenoviruses, adeno-associated viruses, retroviruses, lentiviruses, alphaviruses, and herpesviruses are a few of the most common candidates for use as therapeutic agents or efficient gene delivery systems. Efforts are being made to improve and perfect viral-vector-based therapies to overcome potential or reported drawbacks. Some preclinical trials of viral vector vaccines have yielded positive results, indicating their potential as prophylactic or therapeutic vaccine candidates. Utilization of the oncolytic activity of viruses is the future of cancer therapy, as patients will then be free from the harmful effects of chemo- or radiotherapy. This review discusses in vitro and in vivo studies showing the brilliant therapeutic potential of viruses.
Keyphrases
- gene therapy
- cancer therapy
- sars cov
- end stage renal disease
- genetic diversity
- genome wide
- early stage
- newly diagnosed
- ejection fraction
- stem cells
- radiation therapy
- locally advanced
- photodynamic therapy
- prognostic factors
- drug delivery
- squamous cell carcinoma
- gene expression
- patient reported outcomes
- bone marrow
- dna methylation
- quality improvement
- cell therapy
- current status
- genome wide identification
- rectal cancer