HER2 expression on tumor-derived extracellular vesicles and circulating tumor cells in metastatic breast cancer.

Afroditi NanouLeonie Laura ZeuneFrancois-Clement BidardJean-Yves PiergaLeonardus Wendelinus Mathias Marie Terstappen

Published in: Breast cancer research : BCR (2020)

HER2 can be detected on CTCs and tdEVs not expressing CK, and these CK- CTCs/tdEVs have similar clinical relevance to CTCs and tdEVs expressing CK. tdEVs perform better than CTCs in predicting the HER2 status of the primary tissue. CTC and tdEV heterogeneity in the blood of patients is inversely associated with overall survival.

Keyphrases

circulating tumor cells
metastatic breast cancer
circulating tumor
protein kinase
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
single cell
patient reported
free survival
cell free