Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.
Mohamad SaadAyman El-MenyarKhalid KunjiEhsan UllahJassim Al SuwaidiIftikhar J KulloPublished in: Circulation. Genomic and precision medicine (2022)
Overall, we demonstrate that PRSs derived from European ancestry genome-wide association studies performed well in a Middle Eastern cohort, suggesting these could be used in the clinical setting while ancestry-specific PRSs are developed.