Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo.

Hongzhi LiBohao SunYuting HuangJing ZhangXuejing XuYuqi ShenZhuo ChenJifeng YangLuxi ShenYongwu HuHaihua Gu

Published in: Molecular medicine (Cambridge, Mass.) (2022)

Yeast NDI1 can rescue the defect of oxidative phosphorylation in rotenone-induced PD cell and mouse models, and ameliorate neurobehavioral and neuropathological damages. The results may provide a basis for the yeast NDI1 gene therapy of sporadic PD caused by mitochondrial complex I dysfunction.

Keyphrases

gene therapy
oxidative stress
diabetic rats
high glucose
saccharomyces cerevisiae
mouse model
drug induced
cell wall
single cell
late onset
amyotrophic lateral sclerosis
early onset