Simvastatin attenuates glucocorticoid-induced human trabecular meshwork cell dysfunction via YAP/TAZ inactivation.

Hannah YooAyushi SinghHaiyan LiAna N StratTyler BaguéPreethi S GanapathySamuel Herberg

Published in: Current eye research (2023)

YAP/TAZ inactivation with simvastatin attenuates HTM cell pathobiology in a tissue-mimetic ECM microenvironment. Our data may help explain the association of statin use with a reduced risk of developing glaucoma via indirect YAP/TAZ inhibition as a proposed regulatory mechanism.

Keyphrases

single cell
cell therapy
stem cells
endothelial cells
cardiovascular disease
type diabetes
transcription factor
electronic health record
induced pluripotent stem cells
bone marrow
bone mineral density
mesenchymal stem cells
stress induced
extracellular matrix