Selective Photokilling of Human Pancreatic Cancer Cells Using Cetuximab-Targeted Mesoporous Silica Nanoparticles for Delivery of Zinc Phthalocyanine.

Özge ErSuleyman Gokhan ColakKasim OcakogluMine InceRoger Bresoli-ObachMargarita MoraMaria Lluïsa SagristáFatma YurtSanti Nonell

Published in: Molecules (Basel, Switzerland) (2018)

Imidazole-capped Cetuximab-targeted mesoporous silica nanoparticles are excellent vehicles for the selective delivery of ZnPcOBP to pancreatic cancer cells expressing the EGFR receptor. The novel nanosystem appears to be a suitable agent for photodynamic therapy of pancreatic tumors.

Keyphrases

photodynamic therapy
cancer therapy
metastatic colorectal cancer
endothelial cells
wild type
small cell lung cancer
fluorescence imaging
locally advanced
epidermal growth factor receptor
tyrosine kinase
induced pluripotent stem cells
squamous cell carcinoma