Database Analysis on the Relationships Between Nonsteroidal Anti-inflammatory Drug Treatment Variables and Incidence of Acute Myocardial Infarction in Japanese Patients with Osteoarthritis and Chronic Low Back Pain.
Shogo KikuchiKanae TogoNozomi EbataKoichi FujiiNaohiro YonemotoLucy AbrahamTakayuki KatsunoPublished in: Advances in therapy (2021)
In Japanese patients with OA and CLBP, we saw a trend of increased risk for AMI in patients using NSAIDs for more than 5 years. Elderly patients had a higher prevalence of diabetes, hypertension, and other CVD which increased the risk of AMI. Although NSAID patches were preferred to oral NSAIDs in elderly patients, risk for AMI was similar between the two modalities. Therefore, we suggest using NSAIDs carefully, especially in elderly patients and those at risk of developing CVD.
Keyphrases
- acute myocardial infarction
- percutaneous coronary intervention
- end stage renal disease
- anti inflammatory
- risk factors
- left ventricular
- ejection fraction
- newly diagnosed
- chronic kidney disease
- type diabetes
- anti inflammatory drugs
- cardiovascular disease
- rheumatoid arthritis
- knee osteoarthritis
- coronary artery disease
- prognostic factors
- heart failure
- metabolic syndrome
- patient reported outcomes
- emergency department
- adipose tissue
- skeletal muscle
- combination therapy
- electronic health record