Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.

Mustafa TashkandiFaiza AliSaqer AlsaqerThabet AlhousamiAmparo CanoAlberto MartinFernando SalvadorFrancisco PortilloLouis C GerstenfeldMary B GoldringManish V Bais

Published in: International journal of molecular sciences (2019)

Our study demonstrates that systemic LOXL2 adenovirus or LOXL2 genetic overexpression in mice can protect against OA. These findings demonstrate the potential for LOXL2 gene therapy for knee-OA clinical treatment in the future.

Keyphrases

knee osteoarthritis
high fat diet induced
genome wide
copy number
multiple sclerosis
total knee arthroplasty
rheumatoid arthritis
cell proliferation
transcription factor
type diabetes
insulin resistance
wild type
metabolic syndrome
combination therapy
current status
dna methylation
drug induced