microRNA changes in liver tissue associated with fibrosis progression in patients with hepatitis C.
Kendall R Van Keuren-JensenIvana MalenicaAmanda L CourtrightLayla T GhaffariAlex P StarrRaghu P MetpallyTaylor A BeecroftElizabeth W J CarlsonJeffrey A KieferPaul J PockrosJorge RakelaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2015)
Adding measurements of tissue microRNAs acquired during routine biopsies will continue to increase our knowledge of underlying mechanisms of fibrosis. Our goal is that these data, in combination with studies from other researchers and future long-term studies, could be used to enhance the staging accuracy of liver biopsies and expand the surveillance of patients at increased risk for cancer and progression to advanced fibrosis.