Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model.
Lei DengLukasz WojciechChin Wen PngEileen Yiling KohThet Tun AungDorinda Yan Qin KiohEric Chun Yong ChanBenoit MalleretYongliang ZhangGuangneng PengNicholas Robert John GascoigneKevin Shyong-Wei TanPublished in: Cellular and molecular life sciences : CMLS (2022)
The data confirm our hypothesis that Blastocystis ST4 is a beneficial commensal, and the beneficial effects of Blastocystis ST4 colonization is mediated through modulating of the host gut bacterial composition, SCFAs production, and Th2 and Treg responses in different murine colonization models.