Phagosome-regulated mTOR signalling during sarcoidosis granuloma biogenesis.

Elliott D CrouserLandon W LockeMark W JulianSabahattin BicerWolfgang SadeePeter WhiteLarry S Schlesinger

Published in: The European respiratory journal (2021)

Sarcoidosis granulomas exhibit enhanced and sustained intracellular antigen processing and presentation capacities, and related phagolysosome assembly and acidification are required to support mTORc1 signalling to promote sarcoidosis granuloma formation.

Keyphrases

cell proliferation
transcription factor
reactive oxygen species