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Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients.

Julia StomperRuth MeierTobias MaDietmar PfeiferGabriele IhorstNadja Blagitko-DorfsGabriele GreveDennis ZimmerUwe PlatzbeckerAnne HagemeijerIngrid Schmitt-GraeffMichael Lübbert
Published in: Clinical epigenetics (2021)
Perturbations of EZH2 activity in AML/MDS occur on different, genetic and non-genetic levels. Both low EZH2 protein expression and, by trend, EZH2 gene mutations predicted inferior overall survival of AML patients receiving standard chemotherapy.
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