Unveiling Impurities: A Comprehensive RP-HPLC Method for Accurate Atorvastatin Impurity Analysis in Pharmaceuticals Using Accuracy Profile Approach.

Mounir El Kacemi Aimen El Orche Khadija El Bourakadi Yassine Hameda Benchekroun Fouad Echerfaoui Khalid Karrouchi Mustapha Bouatia Miloud El Karbane

Published in: Journal of AOAC International (2024)

This study not only validates a crucial HPLC method for Atorvastatin analysis but also provides insights into the compound's behavior under extreme conditions and its synthesis and degradation pathways. The validated method serves as a cornerstone in pharmaceutical research and quality control, ensuring medication safety and efficacy.

Keyphrases

ms ms
quality control
simultaneous determination
mass spectrometry
high performance liquid chromatography
high resolution
climate change
solid phase extraction