Combination Therapy of Carnosic Acid and Methotrexate Effectively Suppressed the Inflammatory Markers and Oxidative Stress in Experimental Arthritis.

Martin ChrastinaSilvester PoništJaroslav Tóth Szilvia Czigle Ľudmila PaškováVeronika VyletelováKarol ŠvíkKatarína Bauerová

Published in: Molecules (Basel, Switzerland) (2022)

The addition of CA to methotrexate treatment significantly improved its efficacy in decreasing the development of AA by inhibiting the markers of inflammation and oxidative stress.

Keyphrases

oxidative stress
combination therapy
high dose
diabetic rats
dna damage
ischemia reperfusion injury
induced apoptosis
rheumatoid arthritis
heat shock
heat stress
replacement therapy