High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus.
Sarah ReidAndrei AlexssonMartina FrodlundDavid MorrisJohanna K SandlingKarin BolinElisabet SvenungssonAndreas JönsenChristine BengtssonIva GunnarssonVera Illescas RodriguezAnders BengtssonSabine ArveSolbritt Rantapää DahlqvistMaija-Leena ElorantaAnn-Christine SyvänenChristopher SjöwallTimothy James VyseLars RönnblomDag LeonardPublished in: Annals of the rheumatic diseases (2019)
A high GRS is associated with increased risk of organ damage, renal dysfunction and all-cause mortality. Our results indicate that genetic profiling may be useful for predicting outcomes in patients with SLE.