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High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus.

Sarah ReidAndrei AlexssonMartina FrodlundDavid MorrisJohanna K SandlingKarin BolinElisabet SvenungssonAndreas JönsenChristine BengtssonIva GunnarssonVera Illescas RodriguezAnders BengtssonSabine ArveSolbritt Rantapää DahlqvistMaija-Leena ElorantaAnn-Christine SyvänenChristopher SjöwallTimothy James VyseLars RönnblomDag Leonard
Published in: Annals of the rheumatic diseases (2019)
A high GRS is associated with increased risk of organ damage, renal dysfunction and all-cause mortality. Our results indicate that genetic profiling may be useful for predicting outcomes in patients with SLE.
Keyphrases
  • oxidative stress
  • genome wide
  • systemic lupus erythematosus
  • single cell
  • gene expression
  • insulin resistance
  • free survival
  • weight loss