Luteolin as potential treatment for Huntington's disease: Insights from a transgenic mouse model.
Abuelnor MohammedAzza RamadanAyah Moath AlkheratAli Awadallah Ali Mohamed SaeedNadia Al MazroueiFahad T AlsulamiYousef Saeed AlqarniVineetha Bharathan MenonAbdulla Al AmoodiSami Fatehi AbdallaPublished in: CNS neuroscience & therapeutics (2024)
Luteolin holds promise as a therapeutic agent for improving survival outcomes, managing motor dysfunction, and reducing huntingtin aggregates in HD. The findings are of significance as currently, there are no approved therapeutic interventions that reverse HD pathology or slow down its progression.