Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature.
Kyle KreitmanSatheesh P NairJiten P KothadiaPublished in: Case reports in hepatology (2020)
Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months. The medication was discontinued, and she was treated with N-acetylcysteine for seven days. Her liver function tests returned to normal limits after 26 days after admission. The precise mechanism and risk factors of crizotinib-induced hepatotoxicity remain unknown. Physicians should be aware of the potentially lethal side effect caused by crizotinib.
Keyphrases
- liver failure
- hepatitis b virus
- advanced non small cell lung cancer
- drug induced
- high glucose
- risk factors
- diabetic rats
- small cell lung cancer
- squamous cell carcinoma
- primary care
- emergency department
- acute respiratory distress syndrome
- tyrosine kinase
- stress induced
- respiratory failure
- mechanical ventilation
- aortic dissection