Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis.

Ethan Andrew MackMeaghan C DougherAshley GindaCaitlin Q CahillMelissa MurterKevin SchellYvette C TanhehcoVijay BhojAndrew D Fesnak Donald L SiegelTaku KambayashiNicole AquiUna O'Doherty

Published in: Blood (2023)

We show for the first time that red cell exchange (RCE) treats hyperleukocytosis in acute leukemia. RCE provided similar leukoreduction to standard therapeutic leukoreduction and could be superior in patients with severe anemia, monocytic leukemias, or when requiring rapid treatment.

Keyphrases

single cell
cell therapy
chronic kidney disease
early onset
mesenchymal stem cells
bone marrow
combination therapy