CX3C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke.
Gerlinde van der MatenVivien HenckTadeusz WielochKarsten RuscherPublished in: BMC neuroscience (2017)
Results demonstrate that CX3CR1 deficiency affects the morphology of GFP positive microglia located in the proximal peri-infarct region during the first 14 days after tMCAO. Our data also indicate that CX3CR1 deficiency does not affect definite infarct volumes. Modulation of the CX3CR1 pathway may have implication for microglia function contributing to mechanisms of tissue reorganization in the post-ischemic brain.
Keyphrases
- inflammatory response
- neuropathic pain
- acute myocardial infarction
- replacement therapy
- cerebral ischemia
- traumatic brain injury
- atrial fibrillation
- white matter
- heart failure
- multiple sclerosis
- big data
- machine learning
- blood brain barrier
- spinal cord
- binding protein
- percutaneous coronary intervention
- data analysis