Copper-Catalyzed Asymmetric Synthesis of Bicyclo[3.n.1]alkenones.

A series of highly strained bicyclo[3.n.1]alkenones have been successfully constructed in good-to-excellent enantioselectivities and moderate-to-good yields via copper-catalyzed formal [3+3] cycloaddition. The versatile chiral cycloadducts could be selectively converted into various valuable bridge systems, which hold considerable potential for the construction of natural and bioactive compounds containing a [3.n.1] moiety.