Extended Genotyping to Stratify the Risk of CIN2+ in Women with Persistent HPV Infection, Negative Cytology and Type 3 Transformation Zone.
Maria Teresa BrunoGaetano ValentiAntonino Giovanni CavallaroIlenia PalermoTiziana AielloJessica FarinaMarco Marzio PanellaLiliana MereuPublished in: Cancers (2024)
Women with viral persistence, negative cytology, and TZ3 have a 19% risk of CIN2+; genotyping helps stratify risk, but extensive genotyping is necessary instead of partial genotyping (16/18), referring to a population of women over 50 years old in which the prevalence of genotypes 16,18 decreases and the prevalence of other genotypes increases; diagnostic LEEP is excessive (only 16 cases of CIN2+ out of 48 cases treated), even though 83% of women had viral clearance after LEEP; p16/Ki67 double staining could be a potential risk marker, which would only highlight women at risk of CIN2+ to undergo LEEP. To individualize the diagnostic workup and treatment and minimize the risk of under diagnosis and overtreatment, future studies should explore the use of extended genotyping and new biomarkers for individual risk stratification.
Keyphrases
- genome wide
- high throughput
- polycystic ovary syndrome
- cervical cancer screening
- high grade
- genetic diversity
- risk factors
- pregnancy outcomes
- breast cancer risk
- sars cov
- fine needle aspiration
- dna methylation
- gene expression
- squamous cell carcinoma
- metabolic syndrome
- ultrasound guided
- pregnant women
- insulin resistance
- body mass index
- risk assessment
- single cell
- neoadjuvant chemotherapy
- climate change
- lymph node
- skeletal muscle
- newly diagnosed
- physical activity
- human health
- combination therapy
- replacement therapy