Blood coagulation abnormalities in multibacillary leprosy patients.
Débora Santos da SilvaLisandra Antonia Castro TeixeiraDaniela Gois BeghiniAndré Teixeira da Silva FerreiraMárcia de Berredo Moreira PinhoPatricia Sammarco RosaMarli Rambaldi RibeiroMonica Di Calafiori FreireMariana Andrea HackerJosé Augusto da Costa NeryMaria Cristina Vidal PessolaniAna Maria Freire TovarEuzenir Nunes SarnoJonas PeralesFernando Augusto BozzaDanuza EsquenaziRobson Queiroz MonteiroFlavio Alves LaraPublished in: PLoS neglected tropical diseases (2018)
We demonstrated that leprosy MB patients develop a procoagulant status due to high levels of plasmatic fibrinogen, anti-cardiolipin antibodies, von Willebrand factor and soluble tissue factor. We propose that some of these components, fibrinogen for example, presents potential as predictive biomarkers of leprosy reactions, generating tools for earlier diagnosis and treatment of these events.